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Structure and Function of the First Open Reading Frame (ORF1) Protein Encoded by the Human LINE-1 Retrotransposon
(Georgetown University, 2012)
L1 is an autonomous retrotransposable element that replicates to high copy number and has generated over 40% of mammalian DNA. L1 retrotransposition in mammals is a significant source of genetic diversity and defects. Since ...
The Contribution of PCPH to Colon Carcinoma
(Georgetown University, 2011)
PCPH is a well conserved, single-copy gene whose product is ubiquitously expressed but predominates in kidney, liver, and colon. The protein product belongs to the nucleoside triphosphate diphosphohydrolase family, NTPDase, ...
ROLE OF BTG2 IN THE ANTIOXIDANT RESPONSE IN HUMAN BREAST EPITHELIAL CELLS.
(Georgetown University, 2012)
BTG2, a member of antiproliferative gene family BTG/TOB, has been implicated in cell cycle regulation, normal development and tumor suppression. However, the underlying mechanism(s) by which BTG2 regulates these processes ...
The Role of T-LAK Cell-Originated Protein Kinase (TOPK) in Modulating Prostate Cancer Stemness and Androgen Independence
(Georgetown University, 2020)
The predominant clinical challenge in the treatment of prostate cancer (CaP) is how to differentiate aggressive CaP from indolent ones. Previously, our lab has demonstrated that a protein kinase, T-LAK cell-originated ...