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The Role of T Cells in the Hypertension of the Female Dahl Salt-Sensitive Rat
(Georgetown University, 2018)
Hypertension (HT) is a major risk factor for cardiovascular diseases (CVD) and affects 1 billion men and women globally. The underlying cause of HT in women is far less studied than in men. Hence it is critically important ...
The Application of Conditional Reprogramming to Drug Discovery and Regenerative Medicine
(Georgetown University, 2018)
The Conditional Reprogramming (CR) method has been shown to induce an in vitro stem-like state allowing for the continuous growth of patient-derived epithelial cells. Due to this new culture system, it has been possible ...
RARRES1 Modulation of Tubulin Deglutamylation Regulates Metabolism and Cell Survival
(Georgetown University, 2018)
One of the driving mechanisms of cancer progression is the reprogramming of metabolic pathways in intermediary metabolism. Cancers increase their energy expenditure by increasing ATP production for utilization in anabolic ...
Secretion of Cardioprotective Factors from Cardiac Inducing Colonies (CICS) Derived from Germline Pluripotent Stem Cells (HGPSCS) to Combat Myocardial Fibrosis
(Georgetown University, 2021)
Stem cell research for treating or curing myocardial fibrosis has culminated in identifying which scenario is more important; 1) stem cell differentiation into cardiomyocytes that integrate electrically with the heart, 2) ...
A Translational Study of Human 6-O-Endosulfatases in Head and Neck Squamous Cell Carcinoma and Other Malignancies
(Georgetown University, 2021)
Heparan sulfate proteoglycans (HSPGs) regulate growth factor signaling and extracellular matrix remodeling via specific interactions with sulfate groups. 6-O-Sulfation of HSPGs is an impactful modification regulated by the ...
Regulation of Angiotensin Type 1 Receptor Function by an Upstream Short Open Reading Frame (sORF) in the mRNA 5' Leader Sequence
(Georgetown University, 2019)
The angiotensin type 1 receptor (AT1R) plays a critical role in blood pressure control. In this study, we investigated the role of an upstream short open reading frame (sORF) in AT1aR signaling. We investigated Angiotensin ...
The Mechanism of Actin Remodeling by the N-BAR Domain of ASAP1
(Georgetown University, 2020)
Ability to initiate key cellular events relies on engaging cytoskeletal machinery, including remodeling of the actin cytoskeleton and its interactions with the extracellular matrix. Actin remodeling is a dynamic process, ...
Investigation of Potential Targets of Chemotherapy in Ewing Sarcoma and Prostate Cancer
(Georgetown University, 2020)
Cancer-specific features are attractive targets for novel chemotherapies. In Ewing sarcoma, two characteristic features are the cell-surface protein CD99 and the EWS-FLI1 fusion protein. CD99 expression in Ewing sarcoma ...
Identifying and Evaluating Mechanisms of Drug Resistance in Cancer
(Georgetown University, 2019)
Bladder cancer is among the top ten most common cancers, with about ~380,000 new cases and ~150,000 deaths per year worldwide. We have utilized a patient-derived bladder cancer xenograft (PDX) platform to characterize ...
The Role of T-LAK Cell-Originated Protein Kinase (TOPK) in Modulating Prostate Cancer Stemness and Androgen Independence
(Georgetown University, 2020)
The predominant clinical challenge in the treatment of prostate cancer (CaP) is how to differentiate aggressive CaP from indolent ones. Previously, our lab has demonstrated that a protein kinase, T-LAK cell-originated ...