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The Mechanism of Actin Remodeling by the N-BAR Domain of ASAP1
(Georgetown University, 2020)
Ability to initiate key cellular events relies on engaging cytoskeletal machinery, including remodeling of the actin cytoskeleton and its interactions with the extracellular matrix. Actin remodeling is a dynamic process, ...
Investigation of Potential Targets of Chemotherapy in Ewing Sarcoma and Prostate Cancer
(Georgetown University, 2020)
Cancer-specific features are attractive targets for novel chemotherapies. In Ewing sarcoma, two characteristic features are the cell-surface protein CD99 and the EWS-FLI1 fusion protein. CD99 expression in Ewing sarcoma ...
The Role of T-LAK Cell-Originated Protein Kinase (TOPK) in Modulating Prostate Cancer Stemness and Androgen Independence
(Georgetown University, 2020)
The predominant clinical challenge in the treatment of prostate cancer (CaP) is how to differentiate aggressive CaP from indolent ones. Previously, our lab has demonstrated that a protein kinase, T-LAK cell-originated ...