Browsing Department of Neuroscience by Title
Now showing items 1-20 of 98
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A Translational Investigation of Discoidin Domain Receptor 1 Inhibition as a Novel Therapeutics Strategy in Neurodegenerative Disease
(Georgetown University, 2021)Neurodegenerative diseases (ND) are gaining recognition as imminent health crises. The greatest unmet need in neurodegeneration is a disease modifying therapy, but the failures of drug development have not been for a lack ... -
A-ephrins in Neuropsychiatric Spectrum Disorder Models
(Georgetown University, 2014)Neuropsychiatric spectrum disorders such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are frequently comorbid and exhibit overlapping abnormalities in both behavioral symptoms and ... -
The Acquisition of Productive Rules in Child and Adult Language Learners
(Georgetown University, 2017)In natural language, evidence suggests that, while some rules are productive (regular), applying broadly to new words, others are restricted to a specific set of lexical items (irregular). Further, the literature suggests ... -
Acute Microglial Responses to Single Non-Epileptogenic vs. Epileptogenic Seizures in Mouse Hippocampus
(Georgetown University, 2019)As the resident macrophage of the central nervous system, microglia are in a uniquely privileged position to both affect and be affected by neuroinflammation, neuronal activity and injury, which are all hallmarks of seizures ... -
Adolescent Neurocognitive Maturity Mediates Paths to Altered Social Norms and Vulnerability in Emerging Adulthood
(Georgetown University, 2020)The transitional period between adolescence and adulthood is a high-risk period for social strain and adversity leading to experiences of violence and altered normative civic beliefs. In this dissertation, I examine cognitive ... -
Age- and Experience-Dependent Modulation of Coherent Visual Motion Processing
(Georgetown University, 2016)Visual motion processing dysfunction has been observed in developmental dyslexia, but the nature of the relationship between this dorsal stream function and the reading difficulties observed in dyslexia is unclear. This ... -
Alpha-synuclein and its direct effects on microglial activation
(Georgetown University, 2013)Accumulation, deposition and dysfunction of α-synuclein occur in a class of neurodegenerative disorders known as synucleinopathies. These include Parkinson's disease, dementia with Lewy bodies, and multiple system ... -
ALPHA-SYNUCLEIN AND THE MULTIPLE HIT HYPOTHESIS OF PARKINSON'S DISEASE
(Georgetown University, 2012)Alpha-synuclein has been linked to the pathogenesis of Parkinson's disease and other synucleinopathies through its propensity to form toxic oligomers. The exact mechanism for oligomeric synuclein-directed cell vulnerability ... -
The Behavioral and Neural Basis of Emotional Face Processing in Atypically Developing Children and Adolescents
(Georgetown University, 2014)The ability to recognize, interpret, and respond appropriately to the affective facial expressions of others is an important component of non-verbal communication; when face-emotion recognition is impaired there can be ... -
Behavioral Flexibility in Autism Spectrum Disorder: The Role of Memory and Its Neural Correlates
(Georgetown University, 2020)Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder marked by social and behavioral deficits, including pronounced inflexibility. Behavioral interventions often fail to generalize, possibly due to difficulties ... -
The Brain Basis of Arithmetic, Reading and Reading Disability
(Georgetown University, 2013)Reading and arithmetic, both foundational skills essential for classroom success, are symbolic systems that were invented relatively recently in regard to evolutionary history; so recently that the human brain has not ... -
Brain Oscillatory Dynamics of Lexical-Semantic Processing
(Georgetown University, 2013)Neuropsychological and imaging studies have shown that anterior and posterior brain areas are involved in the retrieval and selection of semantic representations, but it is not known how these areas dynamically interact ... -
Cerebellar Involvement in Reading and Math Disabilities
(Georgetown University, 2020)Brain imaging studies have shown that the cerebellum, traditionally associated with motor function (Manto et al., 2012), is active during reading (Martin et al., 2015) and math (Arsalidou & Taylor, 2011). Cognitive deficits ... -
Changes in Hippocampal Synaptic Plasticity Following Exposure to High Frequency Head Impacts (HF-HI)
(Georgetown University, 2020)Concussions account for over 80% of all cases of TBI reported each year. Sustaining multiple concussions is associated with the development of lasting cognitive and memory impairments. Chronic traumatic encephalopathy ... -
Characterization of SOX11 Partner Proteins and Interaction Domains in Xenopus Neurogenesis
(Georgetown University, 2020)During neurogenesis, transcription factors (TFs) regulate each cellular transition from cell cycle exit, to neuronal differentiation and eventual maturation, ensuring that the correct number and class of neurons are ... -
Cholesterol 24S-hydroxylase: Involvement in Brain Injury and Disease.
(Georgetown University, 2008)Here we investigated whether traumatic brain injury (TBI) altered the regulation of cholesterol 24S-hydroxylase (Cyp46), an enzyme that converts cholesterol to the more hydrophilic 24S-hydroxycholesterol. We examined changes ... -
A COMPARISON OF FREQUENCY-SPECIFIC ACTIVITY DURING REM SLEEP IN TRAUMA-EXPOSED SUBJECTS WITH PTSD AND RESILIENCE
(Georgetown University, 2014)PTSD can develop following exposure to a traumatic event or events resulting in symptoms of hyperarousal, avoidance and the re-experiencing of events related to the trauma experience. Sleep disturbance may contribute to ... -
Controlling growth cone behavior through substrate patterning
(Georgetown University, 2015)Throughout the process of development, billions of neuronal axons are responsible for navigating through the nervous system and synapsing onto their appropriate targets. To establish their individual paths, neurons are ... -
The development of bursting networks following chemical long term potentiation
(Georgetown University, 2012)Collective rhythmic dynamics from neurons are vital for cognitive functions but how neurons self-organize to produce such activity is not well understood. Attractor-based computational models are a theoretical framework ... -
Distinct Roles for EphA7 Isoforms in Cortical Dendritic Elaboration and Synapse Formation
(Georgetown University, 2017)The cerebral cortex consists of complex circuitry that directs diverse functions. Development of the cortex relies upon precise coordination between inherent genetic programs and environmental signals to create distinct ...
