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EFFECTS OF ALZHEIMER’S DISEASE GENETIC RISK FACTOR APOE4 ON THE NORMAL BRAIN
(Georgetown University, 2016)
Over 70 million Americans inherit the strongest genetic risk factor for Alzheimer’s disease (AD), the E4 allele for apolipoprotein E (APOE4), but have few strategies to reduce their risk. To identify markers associated ...
Alpha-synuclein and its direct effects on microglial activation
(Georgetown University, 2013)
Accumulation, deposition and dysfunction of α-synuclein occur in a class of neurodegenerative disorders known as synucleinopathies. These include Parkinson's disease, dementia with Lewy bodies, and multiple system ...
ELECTRIC FIELDS AND SLOW CORTICAL ACTIVITY
(Georgetown University, 2013)
Electrical activity in the brain gives rise to endogenous electric fields, which are the cause of many signals recorded from the nervous system. Electric fields can also be applied from external sources to modulate the ...
A-ephrins in Neuropsychiatric Spectrum Disorder Models
(Georgetown University, 2014)
Neuropsychiatric spectrum disorders such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are frequently comorbid and exhibit overlapping abnormalities in both behavioral symptoms and ...
Functional Neuroimaging Studies of Simple Finger Movements in Healthy Development and Aging and in Children with Dyslexia
(Georgetown University, 2017)
The functional neuroanatomy of the motor system underlying finger movements has been thoroughly elucidated in young adults. However, less is known about this system at younger and older ages, and in disorders. This ...
PROTEASE INDUCED PLASTICITY: MATRIX METALLOPROTEINASE-1 ACTIVATION OF PROTEASE ACTIVATED RECEPTOR 1 INDUCES NEURONAL STRUCTURAL PLASTICITY
(Georgetown University, 2017)
The brain continues to change long after development ceases. Structural modifications to mature cells in the brain as well as the integration newborn neurons through adult hippocampal neurogenesis contribute to plasticity ...
The Effects of Inflammation on Dorsal Striatal Spiny Projection Neurons
(Georgetown University, 2017)
Neuroinflammation precedes neuronal loss in striatal neurodegenerative diseases and can be exacerbated by the release of proinflammatory molecules by microglia. These molecules can affect trafficking of glutamate receptors. ...
THE ROLE OF CREATINE IN PROMOTING OLIGODENDROCYTE SURVIVAL AND MODULATING AXONAL MITOCHONDRIA IN THE CNS
(Georgetown University, 2017)
Oligodendrocytes maintain neuronal integrity in the central nervous system (CNS). Chronic oligodendrocyte loss, a feature of the demyelinating disorder multiple sclerosis (MS), contributes to axonal dysfunction. Current ...
Establishing the sensitivity of functional near-infrared spectroscopy to cognitive load and state in healthy adults and children with Autism Spectrum Disorder
(Georgetown University, 2017)
Functional near-infrared spectroscopy (fNIRS) is an emerging low-cost noninvasive neuroimaging technique that measures cortical blood flow. While fNIRS has gained interest as a potential alternative to fMRI for use with ...
INVESTIGATING THE CHOLINERGIC REGULATION OF HUMAN LEARNING AND MEMORY USING FUNCTIONAL MAGNETIC RESONANCE SPECTROSCOPY
(Georgetown University, 2016)
Current theories consider the effects of acetylcholine neuromodulation in neuronal ensembles as a bidirectional network modulator: increased levels set network dynamics to process external stimuli, and decreased levels set ...