Search Full Text
Now showing items 1-10 of 28
The Effects of Diet Induced Obesity on Central Nervous System Function of APOE Mice
(Georgetown University, 2021)
APOE4 is the strongest genetic risk factor for Alzheimer’s Disease (AD) and obesity is one of the most common environmental risk factors for AD. With 25% of the population being APOE4 carriers and 40% of the population ...
Multimodal Evidence for Neurocognitive Alterations in Pediatric Obesity
(Georgetown University, 2021)
Pediatric obesity is increasing in prevalence and severity in the United States, with one in five adolescents meeting criteria for overweight (body mass index; BMI for age and sex >85th percentile) and one in three meeting ...
Mapping the Neurocognitive Architecture of Reading
(Georgetown University, 2021)
Reading relies on at least partially dissociable sub-word (sublexical) and word-specific (lexical) processes, which are subserved by somewhat separable neural substrates. Beyond this broad dissociation between sublexical ...
Using Structural MRI to Examine the Neural Bases of Dyslexia, Dyscalculia, and ADHD in Children
(Georgetown University, 2021)
The neuroanatomical differences associated with the developmental disorder attention-deficit/hyperactivity disorder (ADHD) or the learning disabilities (LDs) dyslexia (or reading disability, RD) or dyscalculia (or math ...
Creatine Synthesis and Supplementation Regulates Central Nervous System Postnatal Development and Injury
(Georgetown University, 2021)
Cerebral creatine deficiency syndrome (CCDS) is an inborn error of metabolism characterized by intellectual delays, seizures, and autistic-like behavior. Exactly how endogenously synthesized creatine regulates central ...
Investigating the Architecture and Plasticity of the Auditory System through Spoken Word Recognition
(Georgetown University, 2021)
The auditory cortical system, like the visual cortical system, is thought to be organized into a dual-stream architecture consisting of an anterior ventral and a posterior dorsal stream. Under this framework, the anterior ...
From Perception to Social Connection: Assessing Deficits and Modulation of Empathic Processes to Study Human Social Behavior
(Georgetown University, 2021)
Perceiving and responding to the emotions of other individuals is thought to motivate adaptive social behaviors and help form strong interpersonal connections. Failure or manipulation of the empathic processes that subserve ...
A Translational Investigation of Discoidin Domain Receptor 1 Inhibition as a Novel Therapeutics Strategy in Neurodegenerative Disease
(Georgetown University, 2021)
Neurodegenerative diseases (ND) are gaining recognition as imminent health crises. The greatest unmet need in neurodegeneration is a disease modifying therapy, but the failures of drug development have not been for a lack ...
Organochlorines and Brain Homeostasis: Polychlorinated Biphenyls as Astrocytic Stressors
(Georgetown University, 2021)
Exposure to environmental toxicants is prevalent, hazardous and linked to varied detrimental health outcomes and disease. Polychlorinated biphenyls (PCBs), a class of hazardous organochlorines once widely used for industrial ...
The Learning and Persistence of Aesthetic Values
(Georgetown University, 2021)
Our aesthetic preferences are an integral part of our identity, they define us both as individuals and as members of our cultures. Yet very little is known about how they develop or persist over our lifetimes. Philosophical ...