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Using Structural MRI to Examine the Neural Bases of Dyslexia, Dyscalculia, and ADHD in Children
(Georgetown University, 2021)
The neuroanatomical differences associated with the developmental disorder attention-deficit/hyperactivity disorder (ADHD) or the learning disabilities (LDs) dyslexia (or reading disability, RD) or dyscalculia (or math ...
It Sounds the Way It's Spelled: Orthography Effect Mechanisms in Persons with Aphasia
(Georgetown University, 2022)
The goal of this dissertation was to find converging evidence from behavioral and neuroimaging analyses of the mechanisms of orthographic integration with general language processes. By examining orthography effects, covert ...
Creatine Synthesis and Supplementation Regulates Central Nervous System Postnatal Development and Injury
(Georgetown University, 2021)
Cerebral creatine deficiency syndrome (CCDS) is an inborn error of metabolism characterized by intellectual delays, seizures, and autistic-like behavior. Exactly how endogenously synthesized creatine regulates central ...
Investigating the Architecture and Plasticity of the Auditory System through Spoken Word Recognition
(Georgetown University, 2021)
The auditory cortical system, like the visual cortical system, is thought to be organized into a dual-stream architecture consisting of an anterior ventral and a posterior dorsal stream. Under this framework, the anterior ...
From Perception to Social Connection: Assessing Deficits and Modulation of Empathic Processes to Study Human Social Behavior
(Georgetown University, 2021)
Perceiving and responding to the emotions of other individuals is thought to motivate adaptive social behaviors and help form strong interpersonal connections. Failure or manipulation of the empathic processes that subserve ...
The Effects of Traumatic Brain Injury on Sleep and Circadian Rhythms
(Georgetown University, 2022)
Sleep and circadian rhythm disruptions are prevalent in neurodegenerative diseases, and exacerbate impairments in cognitive function, emotional and physical health. Traumatic brain injury (TBI) is a significant risk factor ...
Language System Plasticity in Healthy Development and After Perinatal Stroke
(Georgetown University, 2022)
Language processing is an extremely important, uniquely human cognitive ability. For well over a century, researchers have sought to understand how the human brain implements a system for instantaneously recognizing and ...
Investigation of the Role of the p75 Neurotrophin Receptor in HIV-1 gp120-associated Synaptic and Neural Injury
(Georgetown University, 2022)
Human immunodeficiency virus type 1 (HIV) remains a tenacious global pandemic nearly 40 years after its initial description in humans, currently affecting greater than 37 million individuals worldwide. Despite significant ...
Neural Circuits of Sensorimotor Gating and Social Behavior in Nonhuman Primates
(Georgetown University, 2022)
The nucleus accumbens (NAc) is a critical limbic-motor interface that is important for both processing reward and generating voluntary and reflexive motor outcomes. The NAc receives dense dopaminergic input from the ventral ...