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Reproducibility and use of myelin imaging methods for the study of adolescent brain development
(Georgetown University, 2017)
Human brains have few myelinated axons at birth and continue to myelinate along a temporal and regional specific pattern into adulthood. This prolonged growth trajectory not only contributes to adaptability in functional ...
TDP-43 Pathology: Elucidation of Mechanisms and Treatment with Tyrosine Kinase Inhibition
(Georgetown University, 2017)
Transactivation response DNA binding protein (TDP-43) is a DNA/RNA binding protein involved in the regulation of thousands of genes via nucleotide binding and alternative splicing of pre-mRNAs. In 2006, it was identified ...
ALPHA-SYNUCLEIN AND THE MULTIPLE HIT HYPOTHESIS OF PARKINSON'S DISEASE
(Georgetown University, 2012)
Alpha-synuclein has been linked to the pathogenesis of Parkinson's disease and other synucleinopathies through its propensity to form toxic oligomers. The exact mechanism for oligomeric synuclein-directed cell vulnerability ...
THE NEURAL SUBSTRATES UNDERLYING BOTH SPELLING AND READING
(Georgetown University, 2012)
Written language forms a cornerstone of human communication and understanding. In order to understand why written language can be used skillfully by some and not by others, it is important to investigate the neural basis ...
Interaction of Attention and Emotion Across Development and Disorder
(Georgetown University, 2012)
This dissertation examines how attention and emotion interact in early visual processing across typical development and in Attention Deficit/Hyperactivity Disorder (ADHD). To investigate early visual processing, we utilized ...
Sequelae of Neonatal Antiepileptic Drug Exposure in Rats
(Georgetown University, 2011)
Antiepileptic drugs (AEDs) are first-line seizure treatments. Despite use in pregnancy and early life, their impact on brain maturation is unclear. This can only be assessed in preclinical models (e.g., rats), as seizures ...
DOPAMINE-REGULATING GENES, EXECUTIVE CONTROL, AND THE NETWORK STRUCTURE OF THE HUMAN BRAIN
(Georgetown University, 2013)
Executive control processes, including working memory (WM), attention, and impulse control, rely on brain networks centered in the prefrontal cortex, and especially on dopaminergic signaling in these networks. The function ...
Brain Oscillatory Dynamics of Lexical-Semantic Processing
(Georgetown University, 2013)
Neuropsychological and imaging studies have shown that anterior and posterior brain areas are involved in the retrieval and selection of semantic representations, but it is not known how these areas dynamically interact ...
Morphine activation of stress pathways alters peripheral immune cell signaling
(Georgetown University, 2008)
Morphine is routinely used as an analgesic for acute and chronic pain often in people at greater risk for infection, in spite of the fact that morphine suppresses immune function. Recent studies indicate that morphine ...
THE ROLE OF LOCAL BDNF SYNTHESIS IN SPINE MORPHOGENESIS
(Georgetown University, 2013)
Dendritic spines are the postsynaptic sites for the vast majority of excitatory synapses in the brain. They are highly dynamic structures that undergo changes in size, shape, and number during development, as well as in ...