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Synapse- and cell-specific plasticity in the mature hippocampus
(Georgetown University, 2014)
The central nervous system (CNS) is a living, breathing electrical circuit which learns and remembers by altering its own connectivity. Neurons, the electrical cells of the CNS, are thought to encode information by adjusting ...
Recognition Memory in Amnestic Mild Cognitive Impairment
(Georgetown University, 2014)
A detailed characterization of the memory impairment in amnestic mild cognitive impairment (aMCI) is important both clinically and in the interests of research. The progressive nature of dementia and the fact that neuronal ...
Experimental Studies of Subdiaphragmatic Vagotomy and Nicotine for Reducing Body Weight
(Georgetown University, 2014)
Melanocortin neural circuits are important regulators of food intake (FI) and body weight (BW). The hypothesis of the first part of my dissertation is that the dorsal motor nucleus of the vagus (DMV) represents an important ...
THE EFFECTS OF ROBOTIC TRAINING AND CORTICAL STIMULATION ON REACHING SKILL AFTER CHRONIC STROKE
(Georgetown University, 2011)
<bold>BACKGROUND: </bold> Reaching in three dimensional (3D) space, crucial for activities of daily living (ADLs), is deficient after stroke. The effects of cortical stimulation on 3D robotic training for patients with ...
A Novel Role for Fyn in ApoER2 Regulation
(Georgetown University, 2014)
Apolipoprotein E Receptor 2 (ApoER2) and the tyrosine kinase Fyn are both members of the Reelin pathway, a signaling pathway essential for the laminar formation of the cortex, hippocampus, and cerebellum during development ...
Examinations of Audiovisual Speech Processes, the McGurk Effect and the Heteromodal Superior Temporal Sulcus in the Human Brain Across Numerous Approaches
(Georgetown University, 2016)
Speech can be perceived through the speech sounds we hear and the facial/lip movements we see. In this dissertation, I explore the fundamental question of how the brain processes audiovisual (AV) speech using different ...
The Brain Basis of Arithmetic, Reading and Reading Disability
(Georgetown University, 2013)
Reading and arithmetic, both foundational skills essential for classroom success, are symbolic systems that were invented relatively recently in regard to evolutionary history; so recently that the human brain has not ...
MECHANISMS OF RECOVERY IN PATIENTS WITH SEVERE ARM IMPAIRMENT AFTER STROKE
(Georgetown University, 2017)
Background: Arm hemiparesis is a common consequence of stroke. Patients with more severe arm impairment demonstrate nonlesioned hemisphere activation during brain imaging of motor function. Determining lesion characteristic ...
The Behavioral and Neural Basis of Emotional Face Processing in Atypically Developing Children and Adolescents
(Georgetown University, 2014)
The ability to recognize, interpret, and respond appropriately to the affective facial expressions of others is an important component of non-verbal communication; when face-emotion recognition is impaired there can be ...
NEUROPATHOLOGICAL AND BEHAVIORAL CHANGES FOLLOWING REPEAT MILD TRAUMATIC BRAIN INJURY
(Georgetown University, 2015)
An estimated 1.7 million Americans will sustain a traumatic brain injury (TBI) every year with approximately two-thirds of those injuries being classified as a mild TBI (mTBI). Injury severity and outcome are affected by ...