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Age- and Experience-Dependent Modulation of Coherent Visual Motion Processing
(Georgetown University, 2016)
Visual motion processing dysfunction has been observed in developmental dyslexia, but the nature of the relationship between this dorsal stream function and the reading difficulties observed in dyslexia is unclear. This ...
The development of bursting networks following chemical long term potentiation
(Georgetown University, 2012)
Collective rhythmic dynamics from neurons are vital for cognitive functions but how neurons self-organize to produce such activity is not well understood. Attractor-based computational models are a theoretical framework ...
Mechanisms Behind the GABA-Mediated Field Potential in Hippocampus in the in vitro 4-aminopyridine Model of Epilepsy
(Georgetown University, 2012)
Local field potentials (LFPs) mediated by GABAergic transmission have been recorded from resected human epileptic brain tissue, as confirmed by blockade of these events upon exposure to GABAergic transmission antagonists, ...
ROLE OF HUD IN REGULATING LOCAL DENDRITIC TRANSLATION OF LONG BDNF 3'UTR TRANSCRIPTS
(Georgetown University, 2012)
Highly specific activity-dependent neuronal responses are necessary for modulating synapses to facilitate learning and memory. I present evidence linking a number of important processes involved in regulating synaptic ...
Evaluating goals: the roles of the orbitofrontal cortex and amygdala
(Georgetown University, 2012)
The orbitofrontal cortex (OFC) and its interactions with the basolateral amygdala (BLA) are critical for goal-directed behavior, especially for adapting to changes in reward value. I investigated the contribution of OFC ...
NEURAL COMPUTATIONS UNDERLYING SPEECH RECOGNITION IN THE HUMAN AUDITORY SYSTEM
(Georgetown University, 2011)
Current theories of speech perception in the human brain propose two separate, hierarchically organized cortical processing streams, a ventral and a dorsal stream. The ventral stream is generally believed to mediate acoustic ...
SLOW GABAERGIC TRANSMISSION DEFICITS IN THE BASOLATERAL AMYGDALA IN A MOUSE MODEL OF FRAGILE-X SYNDROME
(Georgetown University, 2012)
Fragile-X Syndrome (FXS), caused by transcriptional silencing of the fmr1 gene, is the leading cause of inherited intellectual disability. Comorbidities of FXS such as autism are typically linked to excitatory/inhibitory ...
Production, Accumulation and Clearance of Amyloid-beta After Experimental Traumatic Brain Injury
(Georgetown University, 2013)
Traumatic brain injury (TBI) increases levels of the toxic peptide amyloid-beta (Abeta) in the brain. As acute accumulation of Abeta may contribute to secondary injury after TBI, and chronic accumulation of Abeta may ...
Neuronal DNA Double Strand Break Damage and Repair Following Sublethal iGluR Activation, and the Neuroprotective Effects of Melatonin
(Georgetown University, 2013)
DNA double strand break (DSB) damage is among the most lethal forms of DNA damage, and its repair in mature neurons remains largely unexamined, particularly following neuronal excitation. A major cause of DSBs is mediated ...