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Morphine activation of stress pathways alters peripheral immune cell signaling
(Georgetown University, 2008)
Morphine is routinely used as an analgesic for acute and chronic pain often in people at greater risk for infection, in spite of the fact that morphine suppresses immune function. Recent studies indicate that morphine ...
Cholesterol 24S-hydroxylase: Involvement in Brain Injury and Disease.
(Georgetown University, 2008)
Here we investigated whether traumatic brain injury (TBI) altered the regulation of cholesterol 24S-hydroxylase (Cyp46), an enzyme that converts cholesterol to the more hydrophilic 24S-hydroxycholesterol. We examined changes ...