Browsing Department of Microbiology and Immunology by Title
Now showing items 1-20 of 39
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Amino-acid derived 1,2 benzisothiazolinone derivatives as novel small molecule antifungal inhibitors: Characterization and identification of potential genetic targets
(Georgetown University, 2011)A steady increase in the incidence of fungal infections has been observed over the past few decades, and treatment remains challenging especially for immuno-compromised populations. Identification of the ideal therapeutic ... -
Analysis of hepatitis delta virus RNA structure : effects on RNA-protein interactions and viral replication
(Georgetown University, 2008) -
Barcoding of Macaque Hematopoietic Stem and Progenitor Cells: A Robust Platform to Assess Vector Genotoxicity
(Georgetown University, 2019)Gene therapies using integrating retroviral vectors to modify hematopoietic stem and progenitor cells have shown great promise for treatment of immune system and hematologic diseases. However, activation of proto-oncogenes ... -
Building Reslience to Biothreats: An Assessment of Unmet Core Global Health Security Needs
(EcoHealth Alliance, 2019)Global health security is the bulwark against catastrophic public health events. Building this security is a timely and urgent challenge for the world as it faces an increasing rate of emergent and re-emergent infectious ... -
Cell Subsets and Pathogen Recognition Requirements Involved in the Innate Response of Primary Human Monocytes and Dendritic Cells to Toxoplasma gondii
(Georgetown University, 2015)As a major natural host for Toxoplasma gondii, the mouse is widely used for the study of the immune response to this medically important protozoan parasite. However, murine innate recognition of toxoplasma depends on the ... -
Characterization of GII Norovirus VPg Nucleotidylylation and Nucleoside Triphosphate Binding
(Georgetown University, 2016)Human Norovirus (hNoV) is a single-stranded positive-sense RNA virus of Caliciviridae family. It is the major cause of gastroenteritis outbreaks in the United States. The VPg protein of hNoV is a multi-functional protein ... -
Characterizing the Impact of Chronic Filarial Infections on Viral-Specific Immunologic Memory: Mechanisms of Bystander Immune Regulation
(Georgetown University, 2023)Filarial infections alter the immune environment through a variety of mechanisms including shaping the T cell subset repertoire and by affecting the function of antigen presenting cells. This, in turn, leads to diminished ... -
Development of a Novel Transfection System to Study Regulation of Hepatitis Delta Virus RNAs by Hepatitis Delta Antigen
(Georgetown University, 2019)Hepatitis delta virus (HDV) is a unique pathogen that co-infects with hepatitis B virus and increase the severity of acute and chronic liver disease. HDV is a negative stranded RNA virus and produces three processed RNAs ... -
Dissecting Malarial Anemia Using Rodent Malaria Models
(Georgetown University, 2021)Malaria continues to be a global issue, with many deaths arising from severe malaria anemia. Rodent malaria models are a well-known tool for studying malaria disease pathology. Initial microarray data revealed changes to ... -
Double-Stranded RNA Acts as a PAMP During Hepatitis Delta Virus Replication
(Georgetown University, 2023)Hepatitis D virus (HDV) is a unique human pathogen that requires hepatitis B virus (HBV) surface antigen to infect the liver. Coinfection of chronic or acute HDV exacerbates the natural disease progression of HBV infection ... -
Endothelial responses to anthrax lethal toxin and pathogenic implications
(Georgetown University, 2010) -
Examining the Role of STATs and STAT Signaling the Induction, Enhancement, and Prolonged Duration of Antiviral Activity by IFN-γ and IFN-α2a in Combination with Ribavirin
(Georgetown University, 2014)Interferons (IFNs) were discovered in 1957, yet there are still questions as to how IFNs elicit their antiviral, antiproliferative, and immunomodulatory activities. In addition, IFN-α is part of the standard treatment ... -
From the Evolutionary Arms Race between Human PKR and Poxvirus K3 to the Budding Yeast Pangenome: Advances in Genetic Characterization
(Georgetown University, 2023)Understanding the genetic causes of variation is a primary goal of genetic research. The following describes two accounts towards this goal. The first is an exploration of an evolutionary arms race between the mammalian ... -
Function of PHR1 in Candida albicans cell wall assembly
(Georgetown University, 2011) -
Hijacking the Candida albicans Multidrug Resistant Transporter MDR1 to Potentiate Antifungal Activity
(Georgetown University, 2013)Fungal invasive infections of humans are now called "hidden killers". The rising costs of treatment are associated with inappropriate therapy, defined as delayed intervention, inadequate dosage, or administration of an ... -
Identification of cis-acting elements in the 3'-untranslated region of the dengue virus type 2 RNA that modulate translation and replication
(Georgetown University, 2011)Using the Massively Parallel Genetic Algorithm for RNA folding, we show that the core region of the 3'-untranslated region of the dengue virus (DENV) RNA can form two dumbbell structures (5' and 3'DBs) of unequal frequencies ... -
IL-27 Induces IFM/STAT1-Dependent Genes and Enhances Function of TIGIT+ HIVgag-Specific T Cells
(Georgetown University, 2022)HIV-specific T cells have diminished effector function and fail to control/eliminate the virus. IL-27, a member of the IL-6/IL-12 cytokine superfamily has been shown to inhibit HIV replication. However, whether or not IL-27 ... -
Immune Responses During Resolution of Acute Hepatitis B in Woodchucks and Their Modulation for Treatment of Chronic Hepatitis B
(Georgetown University, 2020)Understanding the innate and adaptive immune responses during resolution of hepatitis B virus (HBV) infection is important for exploring new treatment options for chronic hepatitis B (CHB). Studying acute hepatitis B (AHB) ... -
Interactions with Innate Immunity Determine the Immunogenicity of Adenovirus Vectors Types 5, 28, and 35: Implications for Vaccine Design
(Georgetown University, 2012)Recombinant adenovirus vectors (rAd) have proven to be very effective at inducing antigen-specific, polyfunctional T cell responses. Recombinant adenovirus serotype 5 (rAd5)-based vectors have been extensively studied as ...
