Browsing Department of Microbiology and Immunology by Title
Now showing items 1-35 of 35
-
Amino-acid derived 1,2 benzisothiazolinone derivatives as novel small molecule antifungal inhibitors: Characterization and identification of potential genetic targets
(Georgetown University, 2011)A steady increase in the incidence of fungal infections has been observed over the past few decades, and treatment remains challenging especially for immuno-compromised populations. Identification of the ideal therapeutic ... -
Analysis of hepatitis delta virus RNA structure : effects on RNA-protein interactions and viral replication
(Georgetown University, 2008) -
Barcoding of Macaque Hematopoietic Stem and Progenitor Cells: A Robust Platform to Assess Vector Genotoxicity
(Georgetown University, 2019)Gene therapies using integrating retroviral vectors to modify hematopoietic stem and progenitor cells have shown great promise for treatment of immune system and hematologic diseases. However, activation of proto-oncogenes ... -
Building Reslience to Biothreats: An Assessment of Unmet Core Global Health Security Needs
(EcoHealth Alliance, 2019)Global health security is the bulwark against catastrophic public health events. Building this security is a timely and urgent challenge for the world as it faces an increasing rate of emergent and re-emergent infectious ... -
Cell Subsets and Pathogen Recognition Requirements Involved in the Innate Response of Primary Human Monocytes and Dendritic Cells to Toxoplasma gondii
(Georgetown University, 2015)As a major natural host for Toxoplasma gondii, the mouse is widely used for the study of the immune response to this medically important protozoan parasite. However, murine innate recognition of toxoplasma depends on the ... -
Characterization of GII Norovirus VPg Nucleotidylylation and Nucleoside Triphosphate Binding
(Georgetown University, 2016)Human Norovirus (hNoV) is a single-stranded positive-sense RNA virus of Caliciviridae family. It is the major cause of gastroenteritis outbreaks in the United States. The VPg protein of hNoV is a multi-functional protein ... -
Development of a Novel Transfection System to Study Regulation of Hepatitis Delta Virus RNAs by Hepatitis Delta Antigen
(Georgetown University, 2019)Hepatitis delta virus (HDV) is a unique pathogen that co-infects with hepatitis B virus and increase the severity of acute and chronic liver disease. HDV is a negative stranded RNA virus and produces three processed RNAs ... -
Dissecting Malarial Anemia Using Rodent Malaria Models
(Georgetown University, 2021)Malaria continues to be a global issue, with many deaths arising from severe malaria anemia. Rodent malaria models are a well-known tool for studying malaria disease pathology. Initial microarray data revealed changes to ... -
Endothelial responses to anthrax lethal toxin and pathogenic implications
(Georgetown University, 2010) -
Examining the Role of STATs and STAT Signaling the Induction, Enhancement, and Prolonged Duration of Antiviral Activity by IFN-γ and IFN-α2a in Combination with Ribavirin
(Georgetown University, 2014)Interferons (IFNs) were discovered in 1957, yet there are still questions as to how IFNs elicit their antiviral, antiproliferative, and immunomodulatory activities. In addition, IFN-α is part of the standard treatment ... -
Function of PHR1 in Candida albicans cell wall assembly
(Georgetown University, 2011) -
Hijacking the Candida albicans Multidrug Resistant Transporter MDR1 to Potentiate Antifungal Activity
(Georgetown University, 2013)Fungal invasive infections of humans are now called "hidden killers". The rising costs of treatment are associated with inappropriate therapy, defined as delayed intervention, inadequate dosage, or administration of an ... -
Identification of cis-acting elements in the 3'-untranslated region of the dengue virus type 2 RNA that modulate translation and replication
(Georgetown University, 2011)Using the Massively Parallel Genetic Algorithm for RNA folding, we show that the core region of the 3'-untranslated region of the dengue virus (DENV) RNA can form two dumbbell structures (5' and 3'DBs) of unequal frequencies ... -
IL-27 Induces IFM/STAT1-Dependent Genes and Enhances Function of TIGIT+ HIVgag-Specific T Cells
(Georgetown University, 2022)HIV-specific T cells have diminished effector function and fail to control/eliminate the virus. IL-27, a member of the IL-6/IL-12 cytokine superfamily has been shown to inhibit HIV replication. However, whether or not IL-27 ... -
Immune Responses During Resolution of Acute Hepatitis B in Woodchucks and Their Modulation for Treatment of Chronic Hepatitis B
(Georgetown University, 2020)Understanding the innate and adaptive immune responses during resolution of hepatitis B virus (HBV) infection is important for exploring new treatment options for chronic hepatitis B (CHB). Studying acute hepatitis B (AHB) ... -
Interactions with Innate Immunity Determine the Immunogenicity of Adenovirus Vectors Types 5, 28, and 35: Implications for Vaccine Design
(Georgetown University, 2012)Recombinant adenovirus vectors (rAd) have proven to be very effective at inducing antigen-specific, polyfunctional T cell responses. Recombinant adenovirus serotype 5 (rAd5)-based vectors have been extensively studied as ... -
Intranasal Vaccination with Murine Cytomegalovirus Expressing Respiratory Syncytial Virus Antigens Promotes Tissue-resident Memory CD8+ T cells
(Georgetown University, 2015)Cytomegalovirus (CMV) vectors are a promising vaccine strategy aimed at eliciting effector CD8+ T cells. CMV-based vaccines have been shown to mediate protection against viral pathogens including simian immunodeficiency ... -
Investigating the Initiation Site of Hepatitis Delta Virus Genome Synthesis
(Georgetown University, 2022)Hepatitis delta virus (HDV) is a significant human pathogen that causes acute and chronic liver disease; there is no licensed therapy. HDV is a circular negative-sense single-stranded RNA (ssRNA) virus that produces three ... -
MECHANISMS CONTROLLING HUMAN NOROVIRUS POLYPROTEIN PROCESSING
(Georgetown University, 2015)Noroviruses (NoV) are the prevailing cause of nonbacterial acute gastroenteritis worldwide and pose a significant financial burden on healthcare systems. The human NoV ORF1 encodes a 200 kDa polyprotein which is cleaved ... -
MicroRNA Involvement In The Cisplatin-selected Pleiotropic Multidrug-resistant Phenotype
(Georgetown University, 2012)Drug resistance remains a major obstacle to the successful treatment of cancer. Cancer cells acquire a pleiotropic resistance phenotype to cisplatin (CisPt), conferring cross-resistance to other xenobiotics. This pleiotropic ... -
Opportunities for Enhanced Defense, Military, and Security Sector Engagement in Global Health Security
(EcoHealth Alliance, 2021)Despite years of dedicated resources, the global community remains unable to prevent the appearance of emerging infectious diseases and to reliably mount an optimal response when prevention fails. SARS-CoV-2 is the most ... -
Probing The Flavivirus Life Cycle: Repurposing Amodiaquine as an Inhibitor of Flavivirus Infectivity and Functional Analysis of Flaviviral NS5 in 5'Capping
(Georgetown University, 2013)Dengue virus serotypes 1-4 (DENV1-4) are transmitted by mosquitoes and are the most frequent cause of arboviral infections in the world. Neither vaccine nor antiviral drug is currently available. In this study, we discovered ... -
Rapid, Non-Classical Mechanism of Leukocyte Recruitment to Staphylococcus Aureus Skin Infection
(Georgetown University, 2020)Swift recruitment of phagocytic leukocytes is critical to prevent infections when bacteria breach through the protective layers of the skin. While this process is commonly believed to be dependent on the prior activation ... -
Regulation of the Complement System by Toxoplasma gondii Surface Coat Proteins SRS25, SRS29C, and SRS57
(Georgetown University, 2019)Very little is known about how the protozoan parasite Toxoplasma gondii overcomes the complement system to establish infection. In this dissertation, I found significant differences in C3b deposition between T. gondii Type ... -
THE REGULATORY ROLES OF GAMMA INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE (GILT) IN CELLULAR REDOX HOMEOSTASIS
(Georgetown University, 2011)Redox regulation is critical for a number of cellular functions and has been implicated in the etiology and progression of cardiovascular diseases, neurodegenerative diseases, and cancer. It has been shown that in the ... -
A Risk Assessment and Seir Model of Rift Valley Fever Virus in the State of Florida
(Georgetown University, 2014)Rift Valley fever (RVF) is a mosquito-borne disease of medical and agricultural importance, affecting humans and ungulates in a disease spectrum stretching from mild, self limited illness to serious disease, abortion and ... -
RNA editing in hepatitis delta virus
(Georgetown University, 2008) -
The Role of Affinity and Mechanism of Virus Attachment to Cells in Antibody-Dependent Enhancement and Neutralization of Flaviviruses
(Georgetown University, 2014)Flaviviruses are RNA viruses that cause significant morbidity and mortality worldwide. There are currently no specific therapeutics or clinically licensed vaccines available for a number of flaviviruses, including dengue ... -
The role of Gamma interferon Inducible Lysosomal Thiol reductase (GILT) in immune and cellular functions
(Georgetown University, 2008) -
THE ROLE OF NUCLEAR DOMAIN 10 PROTEINS IN THE HUMAN PAPILLOMAVIRUS LIFECYCLE
(Georgetown University, 2015)The complete lifecycle of human papillomaviruses (HPVs) is tightly linked to the differentiation program of the human epithelium. Upon primary infection, a short burst of viral DNA replication is required to establish the ... -
SIV-Specific CD8+ T Cells are Phenotypically, Functionally, and Clonotypically Distinct Across Lymphoid and Mucosal Tissues
(Georgetown University, 2019)CD8+ T cell responses are necessary for immune control of simian immunodeficiency virus (SIV). However, the key parameters that confer antiviral potency remain elusive, feasibly because most studies to date have been ... -
Tizoxanide (2-hydroxy-N-(5-nitro-2-thiazolyl)benzamide) Inhibits Hepatitis C Virus Replication Through Modulation of NS5A Hyperphosphorylation
(Georgetown University, 2012)Nitazoxanide (NTZ, Alinia®, Romark Laboratories, LC) is a licensed thiazolide anti-infective that is currently in clinical development for the treatment of chronic hepatitis C, but the antiviral mechanism has remained ... -
Unique properties of the canine papillomavirus type II E5 protein
(Georgetown University, 2009) -
Virus-Positive Merkel Cell Carcinoma Specific T Cells Are Robustly Generated from Healthy Donor Blood
(Georgetown University, 2020)Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin tumor with a five-year relative survival rate of 20%. Clonal integration of Merkel cell polyomavirus (MCPyV) drives approximately 80% of MCC cases ...
