Gene therapies using integrating retroviral vectors to modify hematopoietic stem and progenitor cells have shown great promise for treatment of immune system and hematologic diseases. However, activation of proto-oncogenes ...

Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin tumor with a five-year relative survival rate of 20%. Clonal integration of Merkel cell polyomavirus (MCPyV) drives approximately 80% of MCC cases ...