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THE REGULATORY ROLES OF GAMMA INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE (GILT) IN CELLULAR REDOX HOMEOSTASIS
(Georgetown University, 2011)
Redox regulation is critical for a number of cellular functions and has been implicated in the etiology and progression of cardiovascular diseases, neurodegenerative diseases, and cancer. It has been shown that in the ...
Barcoding of Macaque Hematopoietic Stem and Progenitor Cells: A Robust Platform to Assess Vector Genotoxicity
(Georgetown University, 2019)
Gene therapies using integrating retroviral vectors to modify hematopoietic stem and progenitor cells have shown great promise for treatment of immune system and hematologic diseases. However, activation of proto-oncogenes ...
Virus-Positive Merkel Cell Carcinoma Specific T Cells Are Robustly Generated from Healthy Donor Blood
(Georgetown University, 2020)
Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin tumor with a five-year relative survival rate of 20%. Clonal integration of Merkel cell polyomavirus (MCPyV) drives approximately 80% of MCC cases ...