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Probing The Flavivirus Life Cycle: Repurposing Amodiaquine as an Inhibitor of Flavivirus Infectivity and Functional Analysis of Flaviviral NS5 in 5'Capping
(Georgetown University, 2013)
Dengue virus serotypes 1-4 (DENV1-4) are transmitted by mosquitoes and are the most frequent cause of arboviral infections in the world. Neither vaccine nor antiviral drug is currently available. In this study, we discovered ...
The Role of Affinity and Mechanism of Virus Attachment to Cells in Antibody-Dependent Enhancement and Neutralization of Flaviviruses
(Georgetown University, 2014)
Flaviviruses are RNA viruses that cause significant morbidity and mortality worldwide. There are currently no specific therapeutics or clinically licensed vaccines available for a number of flaviviruses, including dengue ...