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THE REGULATORY ROLES OF GAMMA INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE (GILT) IN CELLULAR REDOX HOMEOSTASIS
(Georgetown University, 2011)
Redox regulation is critical for a number of cellular functions and has been implicated in the etiology and progression of cardiovascular diseases, neurodegenerative diseases, and cancer. It has been shown that in the ...
Identification of cis-acting elements in the 3'-untranslated region of the dengue virus type 2 RNA that modulate translation and replication
(Georgetown University, 2011)
Using the Massively Parallel Genetic Algorithm for RNA folding, we show that the core region of the 3'-untranslated region of the dengue virus (DENV) RNA can form two dumbbell structures (5' and 3'DBs) of unequal frequencies ...
Function of PHR1 in Candida albicans cell wall assembly
(Georgetown University, 2011)
Amino-acid derived 1,2 benzisothiazolinone derivatives as novel small molecule antifungal inhibitors: Characterization and identification of potential genetic targets
(Georgetown University, 2011)
A steady increase in the incidence of fungal infections has been observed over the past few decades, and treatment remains challenging especially for immuno-compromised populations. Identification of the ideal therapeutic ...