Gene therapies using integrating retroviral vectors to modify hematopoietic stem and progenitor cells have shown great promise for treatment of immune system and hematologic diseases. However, activation of proto-oncogenes ...

CD8+ T cell responses are necessary for immune control of simian immunodeficiency virus (SIV). However, the key parameters that confer antiviral potency remain elusive, feasibly because most studies to date have been ...

Hepatitis delta virus (HDV) is a unique pathogen that co-infects with hepatitis B virus and increase the severity of acute and chronic liver disease. HDV is a negative stranded RNA virus and produces three processed RNAs ...

Very little is known about how the protozoan parasite Toxoplasma gondii overcomes the complement system to establish infection. In this dissertation, I found significant differences in C3b deposition between T. gondii Type ...

Global health security is the bulwark against catastrophic public health events. Building this security is a timely and urgent challenge for the world as it faces an increasing rate of emergent and re-emergent infectious ...