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THE REGULATORY ROLES OF GAMMA INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE (GILT) IN CELLULAR REDOX HOMEOSTASIS
(Georgetown University, 2011)
Redox regulation is critical for a number of cellular functions and has been implicated in the etiology and progression of cardiovascular diseases, neurodegenerative diseases, and cancer. It has been shown that in the ...
Examining the Role of STATs and STAT Signaling the Induction, Enhancement, and Prolonged Duration of Antiviral Activity by IFN-γ and IFN-α2a in Combination with Ribavirin
(Georgetown University, 2014)
Interferons (IFNs) were discovered in 1957, yet there are still questions as to how IFNs elicit their antiviral, antiproliferative, and immunomodulatory activities. In addition, IFN-α is part of the standard treatment ...
The Role of Affinity and Mechanism of Virus Attachment to Cells in Antibody-Dependent Enhancement and Neutralization of Flaviviruses
(Georgetown University, 2014)
Flaviviruses are RNA viruses that cause significant morbidity and mortality worldwide. There are currently no specific therapeutics or clinically licensed vaccines available for a number of flaviviruses, including dengue ...
Interactions with Innate Immunity Determine the Immunogenicity of Adenovirus Vectors Types 5, 28, and 35: Implications for Vaccine Design
(Georgetown University, 2012)
Recombinant adenovirus vectors (rAd) have proven to be very effective at inducing antigen-specific, polyfunctional T cell responses. Recombinant adenovirus serotype 5 (rAd5)-based vectors have been extensively studied as ...
Cell Subsets and Pathogen Recognition Requirements Involved in the Innate Response of Primary Human Monocytes and Dendritic Cells to Toxoplasma gondii
(Georgetown University, 2015)
As a major natural host for Toxoplasma gondii, the mouse is widely used for the study of the immune response to this medically important protozoan parasite. However, murine innate recognition of toxoplasma depends on the ...
Intranasal Vaccination with Murine Cytomegalovirus Expressing Respiratory Syncytial Virus Antigens Promotes Tissue-resident Memory CD8+ T cells
(Georgetown University, 2015)
Cytomegalovirus (CMV) vectors are a promising vaccine strategy aimed at eliciting effector CD8+ T cells. CMV-based vaccines have been shown to mediate protection against viral pathogens including simian immunodeficiency ...
MicroRNA Involvement In The Cisplatin-selected Pleiotropic Multidrug-resistant Phenotype
(Georgetown University, 2012)
Drug resistance remains a major obstacle to the successful treatment of cancer. Cancer cells acquire a pleiotropic resistance phenotype to cisplatin (CisPt), conferring cross-resistance to other xenobiotics. This pleiotropic ...
SIV-Specific CD8+ T Cells are Phenotypically, Functionally, and Clonotypically Distinct Across Lymphoid and Mucosal Tissues
(Georgetown University, 2019)
CD8+ T cell responses are necessary for immune control of simian immunodeficiency virus (SIV). However, the key parameters that confer antiviral potency remain elusive, feasibly because most studies to date have been ...
Regulation of the Complement System by Toxoplasma gondii Surface Coat Proteins SRS25, SRS29C, and SRS57
(Georgetown University, 2019)
Very little is known about how the protozoan parasite Toxoplasma gondii overcomes the complement system to establish infection. In this dissertation, I found significant differences in C3b deposition between T. gondii Type ...