Search Full Text
Now showing items 1-6 of 6
Examining the Role of STATs and STAT Signaling the Induction, Enhancement, and Prolonged Duration of Antiviral Activity by IFN-γ and IFN-α2a in Combination with Ribavirin
(Georgetown University, 2014)
Interferons (IFNs) were discovered in 1957, yet there are still questions as to how IFNs elicit their antiviral, antiproliferative, and immunomodulatory activities. In addition, IFN-α is part of the standard treatment ...
The Role of Affinity and Mechanism of Virus Attachment to Cells in Antibody-Dependent Enhancement and Neutralization of Flaviviruses
(Georgetown University, 2014)
Flaviviruses are RNA viruses that cause significant morbidity and mortality worldwide. There are currently no specific therapeutics or clinically licensed vaccines available for a number of flaviviruses, including dengue ...
Cell Subsets and Pathogen Recognition Requirements Involved in the Innate Response of Primary Human Monocytes and Dendritic Cells to Toxoplasma gondii
(Georgetown University, 2015)
As a major natural host for Toxoplasma gondii, the mouse is widely used for the study of the immune response to this medically important protozoan parasite. However, murine innate recognition of toxoplasma depends on the ...
Immune Responses During Resolution of Acute Hepatitis B in Woodchucks and Their Modulation for Treatment of Chronic Hepatitis B
(Georgetown University, 2020)
Understanding the innate and adaptive immune responses during resolution of hepatitis B virus (HBV) infection is important for exploring new treatment options for chronic hepatitis B (CHB). Studying acute hepatitis B (AHB) ...
Regulation of the Complement System by Toxoplasma gondii Surface Coat Proteins SRS25, SRS29C, and SRS57
(Georgetown University, 2019)
Very little is known about how the protozoan parasite Toxoplasma gondii overcomes the complement system to establish infection. In this dissertation, I found significant differences in C3b deposition between T. gondii Type ...
IL-27 Induces IFM/STAT1-Dependent Genes and Enhances Function of TIGIT+ HIVgag-Specific T Cells
(Georgetown University, 2022)
HIV-specific T cells have diminished effector function and fail to control/eliminate the virus. IL-27, a member of the IL-6/IL-12 cytokine superfamily has been shown to inhibit HIV replication. However, whether or not IL-27 ...