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Cover for Interactions with Innate Immunity Determine the Immunogenicity of Adenovirus Vectors Types 5, 28, and 35: Implications for Vaccine Design

Interactions with Innate Immunity Determine the Immunogenicity of Adenovirus Vectors Types 5, 28, and 35: Implications for Vaccine Design

Johnson, Matthew J. (Georgetown University, 2012)

Recombinant adenovirus vectors (rAd) have proven to be very effective at inducing antigen-specific, polyfunctional T cell responses. Recombinant adenovirus serotype 5 (rAd5)-based vectors have been extensively studied as ...

Cover for MicroRNA Involvement In The Cisplatin-selected Pleiotropic Multidrug-resistant Phenotype

MicroRNA Involvement In The Cisplatin-selected Pleiotropic Multidrug-resistant Phenotype

Pouliot, Lynn Margaret (Georgetown University, 2012)

Drug resistance remains a major obstacle to the successful treatment of cancer. Cancer cells acquire a pleiotropic resistance phenotype to cisplatin (CisPt), conferring cross-resistance to other xenobiotics. This pleiotropic ...