Search Full Text
Now showing items 1-3 of 3
Tizoxanide (2-hydroxy-N-(5-nitro-2-thiazolyl)benzamide) Inhibits Hepatitis C Virus Replication Through Modulation of NS5A Hyperphosphorylation
(Georgetown University, 2012)
Nitazoxanide (NTZ, Alinia®, Romark Laboratories, LC) is a licensed thiazolide anti-infective that is currently in clinical development for the treatment of chronic hepatitis C, but the antiviral mechanism has remained ...
Interactions with Innate Immunity Determine the Immunogenicity of Adenovirus Vectors Types 5, 28, and 35: Implications for Vaccine Design
(Georgetown University, 2012)
Recombinant adenovirus vectors (rAd) have proven to be very effective at inducing antigen-specific, polyfunctional T cell responses. Recombinant adenovirus serotype 5 (rAd5)-based vectors have been extensively studied as ...
MicroRNA Involvement In The Cisplatin-selected Pleiotropic Multidrug-resistant Phenotype
(Georgetown University, 2012)
Drug resistance remains a major obstacle to the successful treatment of cancer. Cancer cells acquire a pleiotropic resistance phenotype to cisplatin (CisPt), conferring cross-resistance to other xenobiotics. This pleiotropic ...