Department of Microbiology and Immunology: Recent submissions
Now showing items 1-5 of 35
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IL-27 Induces IFM/STAT1-Dependent Genes and Enhances Function of TIGIT+ HIVgag-Specific T Cells
(Georgetown University, 2022)HIV-specific T cells have diminished effector function and fail to control/eliminate the virus. IL-27, a member of the IL-6/IL-12 cytokine superfamily has been shown to inhibit HIV replication. However, whether or not IL-27 ... -
Investigating the Initiation Site of Hepatitis Delta Virus Genome Synthesis
(Georgetown University, 2022)Hepatitis delta virus (HDV) is a significant human pathogen that causes acute and chronic liver disease; there is no licensed therapy. HDV is a circular negative-sense single-stranded RNA (ssRNA) virus that produces three ... -
Dissecting Malarial Anemia Using Rodent Malaria Models
(Georgetown University, 2021)Malaria continues to be a global issue, with many deaths arising from severe malaria anemia. Rodent malaria models are a well-known tool for studying malaria disease pathology. Initial microarray data revealed changes to ... -
Virus-Positive Merkel Cell Carcinoma Specific T Cells Are Robustly Generated from Healthy Donor Blood
(Georgetown University, 2020)Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin tumor with a five-year relative survival rate of 20%. Clonal integration of Merkel cell polyomavirus (MCPyV) drives approximately 80% of MCC cases ... -
Rapid, Non-Classical Mechanism of Leukocyte Recruitment to Staphylococcus Aureus Skin Infection
(Georgetown University, 2020)Swift recruitment of phagocytic leukocytes is critical to prevent infections when bacteria breach through the protective layers of the skin. While this process is commonly believed to be dependent on the prior activation ...
