Department of Microbiology and Immunology: Recent submissions
Now showing items 1-5 of 23
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Characterization of GII Norovirus VPg Nucleotidylylation and Nucleoside Triphosphate Binding
(Georgetown University, 2016)Human Norovirus (hNoV) is a single-stranded positive-sense RNA virus of Caliciviridae family. It is the major cause of gastroenteritis outbreaks in the United States. The VPg protein of hNoV is a multi-functional protein ... -
Cell Subsets and Pathogen Recognition Requirements Involved in the Innate Response of Primary Human Monocytes and Dendritic Cells to Toxoplasma gondii
(Georgetown University, 2015)As a major natural host for Toxoplasma gondii, the mouse is widely used for the study of the immune response to this medically important protozoan parasite. However, murine innate recognition of toxoplasma depends on the ... -
Intranasal Vaccination with Murine Cytomegalovirus Expressing Respiratory Syncytial Virus Antigens Promotes Tissue-resident Memory CD8+ T cells
(Georgetown University, 2015)Cytomegalovirus (CMV) vectors are a promising vaccine strategy aimed at eliciting effector CD8+ T cells. CMV-based vaccines have been shown to mediate protection against viral pathogens including simian immunodeficiency ... -
THE ROLE OF NUCLEAR DOMAIN 10 PROTEINS IN THE HUMAN PAPILLOMAVIRUS LIFECYCLE
(Georgetown University, 2015)The complete lifecycle of human papillomaviruses (HPVs) is tightly linked to the differentiation program of the human epithelium. Upon primary infection, a short burst of viral DNA replication is required to establish the ... -
MECHANISMS CONTROLLING HUMAN NOROVIRUS POLYPROTEIN PROCESSING
(Georgetown University, 2015)Noroviruses (NoV) are the prevailing cause of nonbacterial acute gastroenteritis worldwide and pose a significant financial burden on healthcare systems. The human NoV ORF1 encodes a 200 kDa polyprotein which is cleaved ...
