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  Modulation of Synaptic Plasticity by Phosphorylation of Amyloid Precursor Protein at Distinct Residues 

  Garcia DuBar, Selena Nicole (Georgetown University, 2023)

  Alzheimer's Disease (AD), the most common neurodegenerative disorder, is characterized by progressive cognitive impairment. Histopathological hallmarks include Aβ accumulation and tau phosphorylation. Aβ formation starts ...
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  Deficiency in CCR5, a Mediator of Neuroinflammation, Normalizes TIMP Levels, Working Memory, and Gamma Oscillation Power in APOE4 Targeted Replacement Mice 

  Greco, Griffin Alexander (Georgetown University, 2023)

  The APOE4 allele increases the risk for Alzheimer’s disease (AD) in a dose-dependent manner and is also associated with cognitive decline in non-demented elderly controls. In mice with targeted gene replacement (TR) of ...
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  Modeling and Simulation of Drug Distribution in the Central Nervous System 

  Heitman, Andrew (Georgetown University, 2022)

  Modeling and simulation can provide not only predictions of the behavior of biological systems in certain circumstances, but also provide insight into the nature of those systems in study. In this thesis, a biological model ...
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  Plk2 Promotes Homeostatic Synaptic Destabilization Through Disruption of N-cadherin Adhesion Complexes During Hyperexcitation 

  Abdel-Ghani , Mai (Georgetown University, 2023)

  Alzheimer’s disease (AD), the most common form of dementia, is characterized by the loss of synapses. N-cadherin is a synaptic cellular adhesion molecule (CAM) that is downregulated in AD. Synaptic plasticity is impaired ...
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  Shisa7-dependent Modulation of GABAA Receptor Kinetics and Pharmacology 

  Castellano, David D (Georgetown University, 2023)

  Throughout the brain, the balance between excitatory and inhibitory signaling is necessary for proper circuit function. GABAA receptors (GABAARs) are pentameric ligand-gated ion channels that provide the vast majority of ...

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