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NEUROPEPTIDE Y RECEPTOR TYPE 5 AS A REGULATORY RECEPTOR IN NPY SYSTEM
(Georgetown University, 2012)
Neuropeptide Y (NPY) is one of the most abundant peptides in the central and peripheral nervous system. It is involved in numerous physiological (e.g. energy and bone homeostasis) and pathophysiological processes (e.g. ...
The Stress Reducing Effects of Acupuncture in a Rat Model of Chronic Stress
(Georgetown University, 2010)
There is a growing body of evidence that links chronic stress to the development of numerous disease processes including cardiovascular disease, cancer and obesity. Electro-acupuncture (EA) is a useful adjunct therapy in ...
Interferon Regulatory Factor-1 (IRF1) Signaling Regulates Apoptosis and Autophagy to Determine Endocrine Responsiveness and Cell Fate in Human Breast Cancer
(Georgetown University, 2013)
Interferon regulatory factor-1 (IRF1) is a nuclear transcription factor and pivotal regulator of cell fate in cancer cells. While IRF1 is known to possess tumor suppressive activities, the role of IRF1 in mediating apoptosis ...
Molecular Mechanisms of Taxane Resistance
(Georgetown University, 2010)
Treatment with the taxanes (Paclitaxel or Docetaxel) is often the therapy of choice for women with breast cancer. In most cases, the taxanes can arrest cell proliferation at the G2/M phase of mitosis and cause cell death. ...