Ethical Considerations in Clinical Trials
Levine, Robert J.
Clinical Pharmacology and Therapeutics 25(5, Part 2): 728-749, May 1979.
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Levine, Robert J.; Dennison, David K. (1997-03)Ethical justification for starting a clinical trial requires at the outset an accurate statement of "no difference" regarding the two or more agents to be compared. This may be expressed as "theoretical equipoise" (no data ...