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dc.creatorLipsett, Mortimer B.en
dc.date.accessioned2015-05-05T18:04:14Zen
dc.date.available2015-05-05T18:04:14Zen
dc.date.created1982-08-27en
dc.date.issued1982-08-27en
dc.identifier10.1001/jama.248.8.941en
dc.identifier.bibliographicCitationJAMA. 1982 Aug 27; 248(8): 941-942.en
dc.identifier.issn0098-7484en
dc.identifier.urihttp://worldcatlibraries.org/registry/gateway?version=1.0&url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&atitle=On+the+Nature+and+Ethics+of+Phase+I+Clinical+Trials+of+Cancer+chemotherapies&title=JAMA.+&volume=248&issue=8&pages=941-942&date=1982&au=Lipsett,+Mortimer+B.en
dc.identifier.urihttp://dx.doi.org/10.1001/jama.248.8.941en
dc.identifier.urihttp://hdl.handle.net/10822/721489en
dc.description.abstractProcedural and ethical aspects of phase I clinical trials of anti-cancer agents are examined to guide physicians in their role as advisors to patients enrolled in such trials. These phase I trials, designed to establish the toxicity and therapeutic potential of the drugs, are conducted in patients with extensive metastatic disease. The question is raised whether these patients are more vulnerable to constraints and inducements that impair a research subject's autonomy, and are therefore in need of additional protection in the consent process. (KIE abstract)en
dc.formatArticleen
dc.languageenen
dc.sourceBRL:KIE/14718en
dc.subjectAutonomyen
dc.subjectCanceren
dc.subjectClinical Trialsen
dc.subjectConsenten
dc.subjectDecision Makingen
dc.subjectDiseaseen
dc.subjectDrugsen
dc.subjectEthicsen
dc.subjectFamily Membersen
dc.subjectHuman Experimentationen
dc.subjectInformed Consenten
dc.subjectNatureen
dc.subjectObligations to Societyen
dc.subjectPatientsen
dc.subjectPhysiciansen
dc.subjectResearchen
dc.subjectResearch Ethicsen
dc.subjectRisks and Benefitsen
dc.subjectTerminally Illen
dc.subjectToxicityen
dc.titleOn the Nature and Ethics of Phase I Clinical Trials of Cancer Chemotherapiesen
dc.provenanceDigital citation created by the National Reference Center for Bioethics Literature at Georgetown University for the BIOETHICSLINE database, part of the Kennedy Institute of Ethics' Bioethics Information Retrieval Project funded by the United States National Library of Medicine.en
dc.provenanceDigital citation migrated from OpenText LiveLink Discovery Server database named NBIO hosted by the Bioethics Research Library to the DSpace collection BioethicsLine hosted by Georgetown University.en


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