Death of Patient Who Was Unwitting Subject of Randomised Controlled Trial of Cancer Treatment
Lancet. 1982 May 1; 1(8279): 1028-1029.
A British case of an elderly widow who received an experimental cancer drug without her consent is reported. The drug led to her death and the case came to public notice. It was revealed that, since 1980, 250 patients were allocated by random selection into one of three experimental groups without being informed that research was underway. Suggestions are made for eliminating deception or nondisclosure in therapeutic trials. (KIE abstract)
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CRIMSON Protocol: A Randomised Controlled Trial of Joint Crisis Plans to Reduce Compulsory Treatment of People With Psychosis Thornicroft, Graham; Farrelly, Simone; Birchwood, Max; Marshall, Max; Szmukler, George; Waheed, Waquas; Byford, Sarah; Dunn, Graham; Henderson, Claire; Lester, Helen; Leese, Morven; Rose, Diana; Sutherby, Kim (2010-11-05)The use of compulsory treatment under the Mental Health Act (MHA) has continued to rise in the UK and in other countries. The Joint Crisis Plan (JCP) is a statement of service users' wishes for treatment in the event of a ...
Brahams, Diana (1984-05-12)The death of a surgical patient, who had reluctantly agreed to participate in a trial of MST Continus, an oral slow-release morphine preparation, demonstrates the importance of informed consent and adequate communication ...