Spina Bifida: Trials Ahead
Nature. 1982 Sep 16-22; 299(5880): 198.
Controversy has erupted in Britain over the ethical implications of an impending clinical trial to investigate the role of folic acid and other multivitamin supplements in the prevention of neural tube defects. The study population will consist of women who had previously conceived a spina bifida child and who are now planning another pregnancy. Some critics, believing there is already sufficient evidence of a folic acid link to spina bifida, object to withholding folic acid from one of the high-risk control groups. Concern has also been expressed about the extent to which participants will be briefed. (KIE abstract)
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