Historical Controls: The Practitioner's Clinical Trials
New England Journal of Medicine. 1982 Nov 18; 307(2l): 1339-1340.
Clinical experience is viewed as a valid, if imperfect, mechanism for ongoing assessment of the safety and effectiveness of newly marketed drugs. Examples are presented of the correction of dosage recommendations and adverse effect data as a result of physician experience. It is also argued that physicians must often rely on their own observations since clinical trials focus, for the most part, on the average performance of a drug in groups of people. (KIE abstract)
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