Patients' Preferences in Randomized Clinical Trials
New England Journal of Medicine. 1984 May 24; 310(21): 1385-1387.
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A Response to a Purported Ethical Difficulty With Randomized Clinical Trials Involving Cancer Patients Freedman, Benjamin (1992)In recent years, for a variety of reasons, the mainstay of clinical investigation -- the randomized controlled clinical trial (RCT) -- has increasingly come under attack. Since Charles Fried's influential monograph, the ...