Pertussis and Pertussis Vaccine: Reanalysis of Benefits, Risks, and Costs
Hinman, Alan R.
Koplan, Jeffrey P.
JAMA. 1984 Jun 15; 251(23): 3109-3113.
An analysis was performed on the experience of a hypothetical cohort of one million children followed from birth to 6 years of age with and without a pertussis vaccination program. The results indicated that a vaccination program reaching 90% of children would reduce disease incidence and disease-related costs by 90%. Based on a conservative approach that considered only direct costs associated with vaccine and vaccine reactions, the authors calculated that the benefit-cost ratio of an immunization program is 11.1:1. They conclude that, until improved vaccines are developed, it is prudent to continue use of present vaccines with careful attention to possible contraindications. (KIE abstract)
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