JAMA. 1985 Dec 20; 254(23): 3353-3357.
Presented here is the first report of an advisory panel on organ transplantation convened by the American Medical Association's Council on Scientific Affairs. This report, approved by the Council in February 1985, reviews experimental work with animal and human xenografts to date and discusses the mechanisms of xenograft rejection, which qualitatively resembles allograft rejection but differs quantitatively depending on the genetic disparity between donor and recipient. Major problems for research include histocompatibility barriers, mechanisms of graft rejection, development of adequate immunosuppressive agents, and investigation of possible infectious agents in animal organs that could be transmitted to human recipients. The report notes that xenografts could provide one approach for resolving organ procurement problems. (KIE abstract)
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Caplan, Arthur L. (1985-12-20)The 1984 implantation of a baboon heart into Baby Fae, a newborn with a fatal heart defect, has created an enormous controversy over the use of xenografts. There is a serious shortage of human kidneys, hearts, and ...