Ethical Issues Raised by Research Involving Xenografts
Caplan, Arthur L.
JAMA. 1985 Dec 20; 254(23): 3339-3343.
The 1984 implantation of a baboon heart into Baby Fae, a newborn with a fatal heart defect, has created an enormous controversy over the use of xenografts. There is a serious shortage of human kidneys, hearts, and livers available for transplantation, and the prevailing system for procuring organs through voluntary donation is not efficient. In the few clinical trials of xenografts in which primate kidneys or hearts have been implanted in humans, the grafts failed within three weeks; both animal and clinical trials are still in a highly experimental state. Because of the organ shortage and lack of alternatives for persons with life-threatening organ failure, the author believes that research involving xenografts in human subjects should not be prohibited but should be regulated and conducted under strict ethical protocols. The author briefly discusses the morality of killing animals to obtain their organs. (KIE abstract)
Adults; Alternatives; Animal Experimentation; Animal Organs; Clinical Ethics; Clinical Ethics Committees; Clinical Trials; Consent; Disclosure; Donors; Drugs; Ethics; Ethics Committees; Federal Government; Government; Hearts; Human Experimentation; Informed Consent; Kidneys; Killing; Life; Livers; Medicine; Minors; Morality; Newborns; Organ Donors; Organ Transplantation; Prevalence; Public Policy; Regulation; Research; Research Ethics; Research Ethics Committees; Risks and Benefits; Scarcity; Terminally Ill; Tissue Transplantation; Transplantation; Xenografts;
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