False Data & the Therapeutic Misconception: Two Urgent Problems in Research Ethics. False Data and Last Hopes: Enrolling Ineligible Patients in Clinical Trials
Vanderpool, Harold Y.
Weiss, Gary B.
Hastings Center Report. 1987 Apr; 17(2): 16-19.
A persistent ethical dilemma in research is the potential conflict between the patient-subject's best interests and the principles of scientific methodology. Vanderpool and Weiss discuss the problem in cancer research when a physician falsifies data in order to increase a patient's chances of being selected to participate in a clinical trial. While raising the question of whether such lying is justified if it may prolong the life of a cancer patient for whom there are no other therapeutic options, the authors point out that the inclusion of ineligible subjects may render trial results invalid. (KIE abstract)
Beneficence; Cancer; Clinical Trials; Common Good; Critically Ill; Deception; Drugs; Ethics; Fraud; Human Experimentation; Investigators; Life; Love; Misconduct; Moral Policy; Motivation; Patients; Physicians; Prognosis; Prolongation of Life; Regulation; Research; Research Design; Research Ethics; Research Subjects; Selection of Subjects; Self Regulation; Terminally Ill; Therapeutic Misconception;
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False Data & the Therapeutic Misconception: Two Urgent Problems in Research Ethics. False Data and Last Hopes: Enrolling Ineligible Patients in Clinical Trials Vanderpool, Harold Y.; Weiss, Gary B. (1987-04)
Appelbaum, Paul S.; Roth, Loren H.; Lidz, Charles W.; Benson, Paul; Winslade, William (1987-04)Using examples from psychiatric research, the authors explore the ethical dilemma of the "therapeutic misconception," where, despite explanation, patient-subjects believe that research protocols are designed to benefit ...