Screening for HIV: Can We Afford the False Positive Rate?
Meyer, Klemens B.
Pauker, Stephen G.
New England Journal of Medicine. 1987 Jul 23; 317(4): 238-241.
Plans to test low-risk populations for human immunodeficiency virus (HIV) antibody tend to ignore the social consequences of false positive results. The authors describe the difficulties and uncertainties that characterize testing for antibody to HIV, the prevalence of infection among various segments of the population, and the statistical meaning of positive tests in different subgroups. They contend that screening of the general population will unavoidably stigmatize and frighten many healthy people and may not substantially reduce the transmission rate for AIDS. They urge that screening not be broadly implemented unless and until we make a deliberate choice of the threshold probability of infection above which we will screen and make explicit the trade-offs implicit in any testing program. (KIE abstract)
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Hagen, Michael D.; Meyer, Klemens B.; Pauker, Stephen G. (1988-03-04)The authors examine data on the risk of human immunodeficiency virus (HIV) infection in various low- and high-risk populations and in surgical personnel. They conclude that the risk of HIV infection to surgeons, nurses, and ...