Gene Therapy in Man: Recommendations of European Medical Research Councils
Lancet. 1988 Jun 4; 2(8597): 1271-1272.
Over the past decade there have been major advances in the understanding at the molecular level of the structure and organisation of the genetic material of living organisms, including man. These advances have been driven by the application of recombinant DNA technology which, despite early concerns, has been used safely in laboratories throughout the world under the regulation of simple guidelines. Animal and human genes have been isolated and characterised; and the appropriate gene products, such as proteins or hormones, have been expressed following the introduction of genes into cultured cells in the laboratory. A further advance--the expression of specific genes after their introduction in laboratory animals--has raised the possibility that certain genetic defects in man might be corrected by applying similar techniques. Discussion of this possibility is well advanced in the USA, and the European Medical Research Councils (EMRC) consider it timely....
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