At What Level of Statistical Certainty Ought a Random Clinical Trial to Be Interrupted?
De Vries, Andre
In: Spicker, Stuart F., et al., eds. The Use of Human Beings in Research. Boston: Kluwer Academic; 1988: 189-225.
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Johnson, Nicholas; Lilford, Richard J.; Brazier, Wayne (1991-03)It has often been argued that if a clinician cannot decide which of two treatments to offer, a trial may be ethical, but it is unethical if she/he has a preference. Since individual clinicians usually have a preference, ...
Spece, Roy G.; Bernstein, Carol (2007-09)This article traces the regulation of [U.S.] Public Health Service ("PHS")-funded research from changes begun with the proposal (1999) and then adoption (2000) of a basic, Uniform Federal ("research misconduct") Policy. ...