Measurement of the False Positive Rate in a Screening Program for Human Immunodeficiency Virus Infections
Burke, Donald S.
New England Journal of Medicine. 1988 Oct 13; 319(15): 961-964.
A study of the frequency of false positive diagnoses in a program screening civilian applicants for U.S. military service for human immunodeficiency virus (HIV) infection suggests that, with adequate attention to program design and quality control, the false positive rate can be kept at an acceptably low level in a low-prevalence population. Serum specimens from the 15 HIV-positive applicants (out of 135,187 tested) were retested by two Western blot methods, revealing 14 unequivocally positive and one negative result, for a false positive rate of 1 in 135,187. The definition of a low-prevalence subpopulation and the factors important in achieving a low false positive rate are discussed. (KIE abstract)
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Measurement of the False Positive Rate in a Screening Program for Human Immunodeficiency Infections Burke, Donald S., (1988-10-13)
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