Why Clinical Trials of AIDS Vaccines Are Premature
Mariner, Wendy K.
American Journal of Public Health. 1989 Jan; 79(1): 86-91.
Considering the current state of scientific knowledge and the fact that no relevant animal model exists for demonstrating a vaccine's probable efficacy, the fundamental prerequisites for testing experimental AIDS vaccines in human beings have not been met. The ethical obligations of informed consent, patient confidentiality, and the balancing of risks and benefits are examined in a call for more public debate on the issue before clinical trials are begun. (KIE abstract)
Aids; Animal Experimentation; Clinical Trials; Compensation; Confidentiality; Consent; Developing Countries; Drug Abuse; Drugs; Duty to Warn; HIV Seropositivity; Human Experimentation; Immunization; Informed Consent; Injuries; Investigators; Knowledge; Moral Obligations; Research; Research Design; Research Subjects; Risks and Benefits; Selection of Subjects; Toxicity; Vaccines;
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