Effect of Antibiotic Treatment on Outcome of Fevers in Institutionalized Alzheimer Patients
Fabiszewski, Kathy J.
JAMA. 1990 Jun 20; 263(23): 3168-3172.
The object of this study was to compare the effectiveness of antibiotic treatment for fever with a palliative approach in a group of hospitalized patients with Alzheimer's disease. One hundred and four patients were divided into three groups, based on the occurrence of fever and on the treatment strategy used, and observed for 34 months. Those who developed fevers had more advanced disease than those who did not. The incidence of fever was similar for the antibiotic and palliative groups, and for the more severely demented patients in each group there was no difference in survival. Among less demented patients those who received antibiotics had a higher rate of survival than those who received palliative treatment. The authors suggest that these observations should be taken into account by health personnel and family members weighing the benefits and burdens of diagnostic workups and treatments in Alzheimer's patients with fevers. (KIE abstract)
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