At What Level of Collective Equipoise Does a Clinical Trial Become Ethical?
Lilford, Richard J.
Journal of Medical Ethics. 1991 Mar; 17(1): 30-34.
It has often been argued that if a clinician cannot decide which of two treatments to offer, a trial may be ethical, but it is unethical if she/he has a preference. Since individual clinicians usually have a preference, most trials could be judged unethical according to this line of argument. A recent important article in the
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Johnson, Nicholas; Lilford, Richard J. and Brazier, Wayne (1991-03)
Ethics of Clinical Trials From a Bayesian and Decision Analytic Perspective: Whose Equipoise Is It Anyway? Lilford, Richard J. (2003-05-03)
Hanson, Wes; Arron, Deborah L.; Brill, Steven; Carroll, Nicholas; Conlin, Roxanne Barton; Daigneault, Michael G.; Drinan, Robert F.; Fry, William R.; Gamble, Cameron C.; Higginbotham, Patrick E.; Hazard, Geoffrey C.; Jermany, CAtherine Elias; Johnson, Judy; Liman, Arthur L.; Littlefield, Wilbur F.; Luban, DAvid J.; McWilliams, J. Michael; Rhode, Deborah L.; Rodgers, T.J.; Rosner, Seth; Saferstein, Harvey I.; Seitz, Patricia A.; Spence, Gerry; Tucker, Dorothy M.; Wiley (1993)