Pregnancy Potential of Human Oocytes -- the Effect of Cryopreservation
New England Journal of Medicine. 1990 Oct 25; 323(17): 1153-1156.
In vitro fertilization with embryo transfer rarely produces a pregnancy rate of greater than 25% per cycle. The authors designed a study to investigate two questions: does the high failure rate result from inadequate technique, or does it represent the maximum potential of retrieved eggs to produce a pregnancy?, and to what extent does freezing embryos affect their capacity to implant? The study was conducted with patients in an egg donation program in Israel. Cohorts of eggs were retrieved from donors. After fertilization, donors received fresh embryos while recipients of donated eggs were randomized to receive either fresh or frozen embryos. The pregnancy success rate was greater in recipients of fresh embryos, leading the authors to conclude that the majority of eggs in a retrieved cohort possess the potential to produce a pregnancy, but that freezing embryos significantly reduces their capacity for implantation. (KIE abstract)
Showing items related by title, author, creator and subject.
Levran, David (1990-10-25)In vitro fertilization with embryo transfer rarely produces a pregnancy rate of greater than 25% per cycle. The authors designed a study to investigate two questions: does the high failure rate result from inadequate technique, ...
Levran, David; Dor, Jehoshua; Rudak, Edwina; Nebel, Laslo, (1990-10-25)
Paynter, S.J. (2000-09)