Maternal Outcome After Open Fetal Surgery: A Review of the First 17 Human Cases
Longaker, Michael T.
Golbus, Mitchell S.
Filly, Roy A.
Rosen, Mark A.
Chang, Sophia W.
Harrison, Michael R.
JAMA. 1991 Feb 13; 265(6): 737-741.
The authors describe their experience with 17 highly selected women who underwent hysterotomy for fetal surgery for complex anomalies and then cesarean delivery through the Fetal Treatment Program at the University of California, San Francisco. Maternal risk of mortality, morbidity, and reproductive potential after fetal surgery were assessed. There were no deaths or serious maternal injuries, although the 14 women who continued their pregnancies experienced uterine irritability and preterm labor followed by premature delivery. Seven of the 17 women had eight subsequent normal pregnancies. The authors conclude from their experience that hysterotomy for fetal surgery can be performed without endangering a woman's life or her future fertility. Uterine irritability and premature labor remain serious problems. The authors believe that now is the time to rigorously examine the efficacy, safety, and cost-effectiveness of fetal therapies before they become accepted treatment. (KIE abstract)
Cesarean Section; Congenital Disorders; Counseling; Evaluation; Fetal Therapy; Fetuses; Fertility; Infertility; Injuries; Life; Morbidity; Mortality; Pregnant Women; Prematurity; Reproduction; Review; Risk; Risks and Benefits; Selection for Treatment; Surgery; Survey; Technology; Technology Assessment;
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