Patients' Willingness to Enter Clinical Trials: Measuring the Association With Perceived Benefits and Preference for Decision Participation
Social Science and Medicine. 1991; 32(1): 35-42.
Patients who agree and those who refuse clinical trial entry may differ in attitudes towards decision control and the benefits associated with the trial arms. These differences, if they exist, have implications for the process of obtaining informed consent and for the generalization of the results of a clinical trial. This paper describes the development and initial application of methods designed to detect such differences....Initial application involved modifying these instruments in terms of an actual chemotherapeutic trial for colonic adenocarcinoma, seeking responses to these measures from 60 non-eligible colorectal cancer patients, then determining whether those who would agree to trial entry differed systematically on these measures from those who indicated that they would refuse such a trial....
Alternatives; Attitudes; Cancer; Clinical Trials; Communication; Comprehension; Consent; Decision Making; Disclosure; Drugs; Evaluation; Evaluation Studies; Human Experimentation; Informed Consent; Life; Methods; Motivation; Patient Participation; Patients; Physician Patient Relationship; Physicians; Prognosis; Random Selection; Research; Research Design; Research Subjects; Statistics; Survey; Value of Life; Values;
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Patients' Willingness to Enter Clinical Trials: Measuring the Association With Perceived Benefit and Preference for Decision Participation Llewellyn-Thomas, H.A.; McGreal, M.J.; Thiel, E.C.; Fine, S. and Erlichman, C. (1991)