A Preliminary Report on Oocyte Donation Extending Reproductive Potential to Women Over 40
Sauer, Mark V.
Paulson, Richard J.
Lobo, Rogerio A.
New England Journal of Medicine. 1990 Oct 25; 323(17): 1157-1160.
To test the efficacy of egg donation in older women, seven women aged 40-44 with ovarian failure were enrolled in a trial of hormone replacement and embryo transfer. Oocytes from young fertile women were recovered after ovarian hyperstimulation and fertilized. The resulting embryos were transferred to the seven recipients after hormonal stimulation of the endometrium. Six pregnancies were established which resulted in one miscarriage, one stillbirth, and the birth of five normal infants, including one set of twins. The outcomes were compared with those in a group of women under 40 who were undergoing the same treatment, and in a groups of infertile, ovulating women 40 and older who were undergoing standard in vitro fertilization and embryo transfer. The authors conclude from their preliminary findings that the use of donated ova together with hormonal stimulation of the endometrium provides older women with ovarian failure a reasonable chance of being pregnant. (KIE abstract)
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