Neonatal Extracorporeal Membrane Oxygenation: How Not to Assess Novel Technologies
Elliott, Stephen J.
Lancet. 1991 Feb 23; 337(8739): 476-478.
Use of extracorporeal membrane oxygenation (ECMO) in neonatal respiratory insufficiency has greatly increased in the USA. The US Neonatal ECMO Registry, maintained at the University of Michigan, reports that 393 infants had been treated with ECMO up to the end of 1985, but this figure had risen to 3577 infants by the end of 1989. Use of this technique in neonatal patients raises important issues which may apply to the introduction of any novel therapeutic intervention, and to assessment of its efficacy.
Alternatives; Biomedical Technologies; Congenital Disorders; Critically Ill; Consent; Evaluation; Human Experimentation; Infants; Minors; Morbidity; Mortality; Newborns; Parental Consent; Patient Care; Patients; Pediatrics; Random Selection; Research; Research Design; Risks and Benefits; Statistics; Technology; Technology Assessment; Therapeutic Research;
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Mike, Valerie; Krauss, Alfred N.; Ross, Gail S. (1993-12)Neonatal extracorporeal membrane oxygenation (ECMO), a technology for the treatment of respiratory failure in newborns, is used as a case study to examine statistical and ethical aspects of clinical trials and to illustrate ...