When to Stop a Clinical Trial
Pocock, Stuart J.
BMJ (British Medical Journal). 1992 Jul 25; 305(6847): 235-240.
This article focuses on the ethical dilemma of when to stop a clinical trial and places statistical stopping rules in the context of such ethical decision making. Other issues include the organisation of data monitoring committees and the problems of premature publication and exaggerated estimation in trials that stop early. Several topical examples are used to convey the relevance of these issues to current practice.
Cancer; Confidentiality; Data Monitoring Committees; Decision Making; Drugs; Editorial Policies; Guidelines; Heart Diseases; HIV Seropositivity; Human Experimentation; Medicine; Methods; Mortality; Newborns; Preventive Medicine; Radiology; Random Selection; Research; Research Design; Risks and Benefits; Standards; Statistics; Therapeutic Research; Uncertainty;
Showing items related by title, author, creator and subject.