Germ-Line Therapy to Cure Mitochondrial Disease: Protocol and Ethics Of
Rubenstein, Donald S.
Thomasma, David C.
Schon, Eric A.
Zinaman, Michael J.
Cambridge Quarterly of Healthcare Ethics. 1995 Summer; 4(3): 316-339.
The combination of genuine ethical concerns and fear of learning to use germ-line therapy for human disease must now be confronted. Until now, no established techniques were available to perform this treatment on a human. Through an integration of several fields of science and medicine, we have developed a nine step protocol at the germ-line level for the curative treatment of a genetic disease. Our purpose in this paper is to provide the first method to apply germ-line therapy to treat those not yet born, who are destined to have a life threatening, or a severely debilitating genetic disease. We hope this proposal will initiate the process of a thorough analysis from both the scientific and ethical communities. As such, this proposal can be useful for official groups studying the advantages and disadvantages of germ-line therapy.
Autonomy; Cells; Diagnosis; Disease; Economics; Embryo Transfer; Ethics; Freedom; Future Generations; Gene Therapy; Genetic Disorders; Genetic Enhancement; Germ Cells; Investigators; Life; Medicine; Methods; Moral Obligations; Moral Policy; Ovum; Parents; Preimplantation Diagnosis; Preventive Medicine; Research; Science; Therapeutic Research; Transplantation;
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Germ-Line Therapy to Cure Mitochondrial Disease: Protocol and Ethics of In Vitro Ovum Nuclear Transplantation Rubenstein, Donald S.; Thomasma, David C.; Schon, Eric A.; Zinaman, Michael J. (1995-06)
Germ-Line Therapy for Mitochondrial Disease: Some Ethical Objections [Response to "Germ Line Therapy to Cure Mitochondrial Disease: Protocol and Ethics of In Vitro Ovum Nuclear Transplantation" by Donald S. Rubenstein, David C. Thomasma, Eric A. Schon, and Michael J. Zinaman (CQ Vol. 4, No. 3)] Watt, Helen (1999-01)
Response to "Germ-Line Therapy to Cure Mitochondrial Disease: Protocol and Ethics of in Vitro Ovum Nuclear Transplantation" by Donald S. Rubenstein, David C. Thomasma, Eric A. Schon, and Michael J. Zinaman ( Bacchetta, Matthew D.; Richter, Gerd (1996)As a result of the dramatic advances made in molecular biology, gene therapy has become viable. The initial endeavors were with monogenetic disorders, but gene therapy may also be of benefit in cancer therapy and treatment ...