Germ-Line Therapy to Cure Mitochondrial Disease: Protocol and Ethics Of
Rubenstein, Donald S.
Thomasma, David C.
Schon, Eric A.
Zinaman, Michael J.
Cambridge Quarterly of Healthcare Ethics. 1995 Summer; 4(3): 316-339.
The combination of genuine ethical concerns and fear of learning to use germ-line therapy for human disease must now be confronted. Until now, no established techniques were available to perform this treatment on a human. Through an integration of several fields of science and medicine, we have developed a nine step protocol at the germ-line level for the curative treatment of a genetic disease. Our purpose in this paper is to provide the first method to apply germ-line therapy to treat those not yet born, who are destined to have a life threatening, or a severely debilitating genetic disease. We hope this proposal will initiate the process of a thorough analysis from both the scientific and ethical communities. As such, this proposal can be useful for official groups studying the advantages and disadvantages of germ-line therapy.
Autonomy; Cells; Diagnosis; Disease; Economics; Embryo Transfer; Ethics; Freedom; Future Generations; Gene Therapy; Genetic Disorders; Genetic Enhancement; Germ Cells; Investigators; Life; Medicine; Methods; Moral Obligations; Moral Policy; Ovum; Parents; Preimplantation Diagnosis; Preventive Medicine; Research; Science; Therapeutic Research; Transplantation;
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