Why African Americans May Not Be Participating in Clinical Trials
Gorelick, Philip B.
Journal of the National Medical Association. 1996 Oct; 88(10): 630-634.
African Americans have been underrepresented in clinical trials. This study was designed to determine factors that may help explain the low participation rate of African Americans in clinical trials. A historical review documented past medical experimentation and other practices on blacks that were often brutal and unethical. These experiences may have served to fortify the legacy of African-American mistrust in the medical system and culminated in the infamous Tuskegee Syphilis Study. Four major barriers to participation in clinical trials were identified: lack of awareness about trials, economic factors, communication issues, and mistrust. These barriers, as well as others, can be surmounted with proper pretrial planning, patient education, genuine commitment and concern by study staff, and hard work to overcome deficiencies.
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The Recruitment Triangle: Reasons Why African Americans Enroll, Refuse to Enroll, or Voluntarily Withdraw From a Clinical Trial: An Interim Report From the African-American Antiplatelet Stroke Prevention Study (AAASPS) Gorelick, Philip B.; Harris, Yvonne; Burnett, Barbara; Bonecutter, Faith J. (1998-03)Recruitment and retention of study subjects are key to the success of a clinical trial. In the case of minority patients, this may be challenging as minority patients have been underserved by the medical health-care system. ...
Establishing a Community Network for Recruitment of African Americans Into a Clinical Trial: The African-American Antiplatelet Stroke Prevention Study (AAASPS) Experience Gorelick, Philip B.; Richardson, DeJuran; Hudson, Edsel; Perry, Charmaine; Robinson, Dorothy; Brown, Nellie; Harris, Yvonne (1996-11)